Leukemic Cells Manipulate MSCs Bioelectrical Signals to Reshape the Bone Marrow Niche
Giulia Borella, Maddalena Benetton, Ambra Da Ros, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi
This study shows that AML blasts alter MSC bioelectrical properties, leading to a pro-leukemic niche, and suggests targeting CaV1.2 could restore normal function.
bioRxiv · Mar 10, 2025 · PreprintCancer Biology