Toll-like receptor 9 contributes in microglial activation and lysosomal dysfunction to promote Alzheimer disease
Moïse de Lavergne, Lucie Mazzola, Katrina Podsypanina, Cecilia Estrella, Philippe Verwaerde, Irini Evnouchidou, Guillaume Darrasse-Jèze, Marie‐Claude Potier, Sheela Vyas, Bénédicte Manoury
This study identifies TLR9's role in microglial activation and lysosomal dysfunction in Alzheimer's disease, showing its inhibition reduces pathology and cognitive defects.
bioRxiv · Jan 18, 2026 · PreprintImmunology