Bénédicte Manoury

Toll-like receptor 9 contributes in microglial activation and lysosomal dysfunction to promote Alzheimer disease

This study identifies TLR9's role in microglial activation and lysosomal dysfunction in Alzheimer's disease, showing its inhibition reduces pathology and cognitive defects.

PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity

This study shows PI3Kδ is critical for dendritic cell function in intestinal immunity by linking microbial sensing to antigen presentation and T-cell activation.

Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease

This study shows that microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer's disease by enhancing lysosomal activity and reducing Aβ clearance.