Cardiomyopathic mutations of lamin A perturb mutual interactions of lamin, nuclear membrane, and chromatin leading to LLPS
Subhradip Nath, Shuvadip Dutta, Shreyasi Dey Sarkar, Duhita Sengupta, Mithun Kumar Mitra, Kaushik Sengupta
This study shows that cardiomyopathic lamin A mutations disrupt nuclear structure and chromatin organisation, leading to liquid-like aggregates and genome spatial disorganisation.
Nucleic Acids Research · Jun 13, 2025Peer-reviewedBiophysics