Author

Kaushik Sengupta

Saha Institute of Nuclear PhysicsORCID 0000-0002-4531-3137Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Shreyasi Dey SarkariD· 2 shared Subhradip NathiD· 2 shared Amrutayani Panda· 1 shared Ayan BanerjeeiD· 1 shared Bhabani Shankar MohantyiD· 1 shared Debasish Prusty· 1 shared Duhita SenguptaiD· 1 shared Kakoli BoseiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

Shreyasi Dey SarkarORCID

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3 papers

Recent·Most cited

Remodelling of chromatin architecture and super-enhancer landscape in lamin A/C depleted HGSOC

Shreyasi Dey Sarkar, Poulami Goswami, Amrutayani Panda, Vishnu S. Mishra, Bhabani Shankar Mohanty, Roli Budhwar, Kakoli Bose, Shuvojit Paul, Ayan Banerjee, Pradip Chaudhari, Kaushik Sengupta

This study investigates the effects of lamin A/C depletion on chromatin organization in HGSOC, finding detethering of gene-poor chromatin, compartment switching, and rewiring of super-enhancers, leading to reduced proliferation.

bioRxiv · Sep 10, 2026 · PreprintCancer Biology

Defects in lamin A-Prohibitin crosstalk leads to ROS elevation and OxPhos imbalance in laminocardiomyopathy

Subhradip Nath, Soumen K. Manna, Debasish Prusty, Sk Ramiz Islam, Kaushik Sengupta

This study shows that the lamin A K97E mutation disrupts PHB2 interaction, causing mitochondrial dysfunction, ROS elevation, and metabolic imbalance, contributing to dilated cardiomyopathy.

bioRxiv · Jul 17, 2025 · PreprintCell Biology

Cardiomyopathic mutations of lamin A perturb mutual interactions of lamin, nuclear membrane, and chromatin leading to LLPS

Subhradip Nath, Shuvadip Dutta, Shreyasi Dey Sarkar, Duhita Sengupta, Mithun Kumar Mitra, Kaushik Sengupta

This study shows that cardiomyopathic lamin A mutations disrupt nuclear structure and chromatin organisation, leading to liquid-like aggregates and genome spatial disorganisation.

Nucleic Acids Research · Jun 13, 2025Peer-reviewedBiophysics