Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ tumor-infiltrating lymphocytes
Hongyan Xie, Aiping Jiang, Aonkon Dey, Joseph W. Dean, Jonathan Perera, Neal Patrick Smith, Alex C. Y. Chen, Seth Anderson, Angelina M. Cicerchia, Ying Hao Sun, William A. Michaud, Maria Florentin, Jacy Fang, Or‐Yam Revach, Tatyana Y. Sharova, , Russell William Jenkins
This study identifies a novel CD8+ TIL subset that uses lymphotoxin and IFN pathways to kill cancer cells, linking LTB expression to clinical response in melanoma.
bioRxiv · Nov 19, 2025 · PreprintCancer Biology