Neal Patrick Smith

The paper identifies a cDC2-Treg feedback circuit in barrier tissues that limits Th2 cell expansion during allergic inflammation.

This study compares T cell phenotypes and clonotypes from bronchoalveolar lavage and endobronchial brushings in healthy controls and allergic asthmatics, finding distinct transcriptional and TCR repertoire features.

This study identifies a novel CD8+ TIL subset that uses lymphotoxin and IFN pathways to kill cancer cells, linking LTB expression to clinical response in melanoma.

The paper identifies a sensory neuron-intrinsic mTORC1 signaling mechanism that establishes neuroimmune memory, enhancing allergic immunity upon allergen re-exposure.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

The paper analyzes 6 million T cells from 91 studies to identify TCR sequence convergence patterns and their association with functional and cellular T cell phenotypes.

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.