Author

Angelina M. Cicerchia

Broad InstituteORCID 0000-0002-0510-2298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Genevieve Marie BolandiD· 2 shared Moshe Sade-FeldmaniD· 2 shared Nir HacoheniD· 2 shared Or‐Yam RevachiD· 2 shared Robert T. MangusoiD· 2 shared Russell William JenkinsiD· 2 shared Seth AndersoniD· 2 shared Aiping JiangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Genevieve Marie BolandORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ tumor-infiltrating lymphocytes

Hongyan Xie, Aiping Jiang, Aonkon Dey, Joseph W. Dean, Jonathan Perera, Neal Patrick Smith, Alex C. Y. Chen, Seth Anderson, Angelina M. Cicerchia, Ying Hao Sun, William A. Michaud, Maria Florentin, Jacy Fang, Or‐Yam Revach, Tatyana Y. Sharova, , Russell William Jenkins

This study identifies a novel CD8+ TIL subset that uses lymphotoxin and IFN pathways to kill cancer cells, linking LTB expression to clinical response in melanoma.

bioRxiv · Nov 19, 2025 · PreprintCancer Biology

CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition

Payal Tiwari, Kayla J. Colvin, Sarah Y. Kim, Ashwin V. Kammula, Jordan M. Chinai, Nuno Alfaiate, Or‐Yam Revach, Erin N. Kistler, Seoyun Heo, Seth Anderson, Sydney M. Moyer, Zhengyang Sun, Angelina M. Cicerchia, Claire A. Palin, Maulik Vyas, , Robert T. Manguso

The paper identifies CREB5 as a driver of immunotherapy resistance in melanoma by promoting collagen matrix deposition, which activates LAIR1 signaling on immune cells.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology