Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance
Jessica M. Phan, Benjamin C. Creekmore, Aivi T. Nguyen, Darya D. Bershadskaya, Nabil F. Darwich, Edward B. Lee
The paper identifies four novel VCP activators that enhance clearance of TDP-43 aggregates in cellular models of multisystem proteinopathy.
bioRxiv · Mar 15, 2023 · PreprintMolecular Biology