Author

Nabil F. Darwich

University of PennsylvaniaORCID 0000-0002-8324-9201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

April ParkiD· 2 shared Benjamin C. CreekmoreiD· 2 shared Edward B. LeeiD· 2 shared James N. PalmeriD· 2 shared Joel C. Thompson· 2 shared Nithin D. AdappaiD· 2 shared Robert J. LeeiD· 2 shared Ryan M. CareyiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

April ParkORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Repositioning of polyubiquitin alters the pathologic tau filament structure

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Courtney L. Smith, Hong Xu, Angelina Baltazar, Sacha P. Salphati, Lakshmi N. Changolkar, Kevt’her Hoxha, Bin Zhang, Caroline M. O’Rourke, George M. Burslem, Virginia M.‐Y. Lee, Yi‐Wei Chang, Edward B. Lee

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

Nature Structural & Molecular Biology · Aug 31, 2026Peer-reviewedNeuroscience

Pseudomonas aeruginosa metabolite 3-oxo-C12HSL induces apoptosis through T2R14 and the mitochondrial calcium uniporter

Zoey A. Miller, Arielle Mueller, Joel C. Thompson, Jordan S. Williams, April Park, Nabil F. Darwich, Yobouet Inès Kouakou, Sarah M. Sywanycz, B. Buchler, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Ryan M. Carey, Robert J. Lee

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

Cell Calcium · May 5, 2026Peer-reviewedPhysiology

Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells

Joel C. Thompson, April Park, Yobouet Inès Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee

This study investigates the effects of pyocyanin and 1-hydroxyphenazine on calcium signaling, mitochondrial function, and cell viability in nasal epithelial cells and cancer cell lines.

International Forum of Allergy & Rhinology · Dec 19, 2025Peer-reviewedPhysiology

Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance

Jessica M. Phan, Benjamin C. Creekmore, Aivi T. Nguyen, Darya D. Bershadskaya, Nabil F. Darwich, Edward B. Lee

The paper identifies four novel VCP activators that enhance clearance of TDP-43 aggregates in cellular models of multisystem proteinopathy.

bioRxiv · Mar 15, 2023 · PreprintMolecular Biology