Author

Karthik Balakrishnan

Mayo ClinicORCID 0000-0002-0244-249XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Ann L. ObergiD· 1 shared Jamie Nadine Bakkum-GameziD· 1 shared Jamison L. VanBlaricom· 1 shared John Weroha· 1 shared Ling Jin· 1 shared Prabhu ThirusanguiD· 1 shared Scott H. KaufmanniD· 1 shared Shruti RaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Ann L. ObergORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Nuclear Cathepsin L Remodels the Replication Machinery to Create a Therapeutic Vulnerability in Ovarian Cancer

Prabhu Thirusangu, Ling Jin, Shruti Rao, Karthik Balakrishnan, Xiaonan Hou, Jamison L. VanBlaricom, Sun-Hee Lee, Ann L. Oberg, John Weroha, Scott H. Kaufmann, Jamie Nadine Bakkum-Gamez, Viji Shridhar

This paper identifies nuclear cathepsin L as a regulator of replication stress in ovarian cancer, showing that its activation creates a therapeutic vulnerability through replication machinery remodeling and DNA repair inhibition.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology