Author

Viji Shridhar

Mayo ClinicORCID 0000-0001-7232-0802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Ann L. ObergiD· 2 shared Jamie Nadine Bakkum-GameziD· 2 shared Jamison L. VanBlaricom· 2 shared John Weroha· 2 shared Ling Jin· 2 shared Prabhu ThirusanguiD· 2 shared Scott H. KaufmanniD· 2 shared Shruti RaoiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Ann L. ObergORCID

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2 papers

Recent·Most cited

Nuclear Cathepsin L Remodels the Replication Machinery to Create a Therapeutic Vulnerability in Ovarian Cancer

Prabhu Thirusangu, Ling Jin, Shruti Rao, Karthik Balakrishnan, Xiaonan Hou, Jamison L. VanBlaricom, Sun-Hee Lee, Ann L. Oberg, John Weroha, Scott H. Kaufmann, Jamie Nadine Bakkum-Gamez, Viji Shridhar

This paper identifies nuclear cathepsin L as a regulator of replication stress in ovarian cancer, showing that its activation creates a therapeutic vulnerability through replication machinery remodeling and DNA repair inhibition.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

Drug-induced nuclear cathepsin L (nCTSL) defines a targetable DNA damage response axis and PARP inhibitor sensitivity in ovarian cancer

Prabhu Thirusangu, Ling Jin, Shruti Rao, Upasana Ray, Anya Zhao, Julie K. Staub, Xinyan Wu, Xiaonan Hou, Jamison L. VanBlaricom, Syed Mohammed Musheer Aalam, Sun-Hee Lee, Ann L. Oberg, Nagarajan Kannan, John Weroha, Jeremy Chien, , Viji Shridhar

This study identifies nuclear cathepsin L (nCTSL) as a biomarker for PARP inhibitor sensitivity in ovarian cancer and shows that combining clofarabine with PARP inhibitors enhances therapeutic response.

Cell Communication and Signaling · Aug 28, 2026Peer-reviewedCancer Biology