ApoE4 causes severe COVID-19 outcomes via downregulation of ACE2
Feng Chen, Yanting Chen, Qiongwei Ke, Yongxiang Wang, Xiongjin Chen, Xiaoping Peng, Yujie Cai, Shennan Li, Yuanhong Sun, Yao Ji, Yuling Jiang, Wenxian Wu, Yan Wang, Lili Cui
This study identifies ApoE4's role in worsening COVID-19 outcomes by downregulating ACE2 expression, reducing Ang II to Ang 1-7 conversion, and increasing SARS-CoV-2 infectivity.
bioRxiv · Sep 4, 2022 · PreprintNeuroscience