FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction
Redin A. Spann, Sora Q. Kim, Md Shahjalal Hossain Khan, Diana A Albarado, Sun Ok Fernandez‐Kim, Hans‐Rudolf Berthoud, David H. McDougal, Heike Münzberg, Yanlin He, Sangho Yu, Christopher D. Morrison
The paper identifies NTS-KLB glutamatergic neurons as critical for mediating FGF21's effects during dietary protein restriction, showing their role in metabolic and behavioral adaptations.
bioRxiv · Apr 19, 2025 · PreprintNeuroscience