Yanlin He

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner

This study shows FoxO1 in the medial preoptic area (MPOA) influences metabolic adaptation to diet and temperature, with effects specific to female mice.

FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction

The paper identifies NTS-KLB glutamatergic neurons as critical for mediating FGF21's effects during dietary protein restriction, showing their role in metabolic and behavioral adaptations.

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

This study shows that FGF21 in the brain enhances the reward value of protein, increasing motivation to consume it during protein restriction.

Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice

This study shows that estrogen signaling through ER and ERβ in 5-HTDRN neurons influences binge drinking behavior in mice, with ER agonists reducing alcohol-induced neuronal activity and binge drinking.

Functional coupling of TRPM2 and NMDARs exacerbates excitotoxicity in ischemic brain injury

The paper identifies a novel mechanism where TRPM2 interacts with NMDARs to enhance excitotoxicity in ischemic stroke and develops a peptide to block this interaction, offering a new therapeutic strategy.