Structure and Dynamics of a Long-Acting Insulin Analog in Hexameric and Dihexameric States
Esra Beyarslan Ayan, Hoang P.M. Nguyen, Hasan DeMi̇rci̇, Türkan Haliloǧlu, İvet Bahar
This study presents X-ray structures of detemir in hexameric and dodecameric forms, revealing structural dynamics and identifying key residues involved in conformational changes and stability.
bioRxiv · Apr 25, 2026 · PreprintBiophysics