Hasan DeMi̇rci̇

Calcium-associated Pro367 ring puckering supports conformational selection in a thermophilic lipase

This paper determines two X-ray crystal structures of a thermophilic lipase, showing that Pro367 ring puckering is associated with calcium binding and conformational selection.

Structure and Dynamics of a Long-Acting Insulin Analog in Hexameric and Dihexameric States

This study presents X-ray structures of detemir in hexameric and dodecameric forms, revealing structural dynamics and identifying key residues involved in conformational changes and stability.

Crystal Structure of 3-Hydroxypropionyl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus

The paper reports the crystal structure of 3-Hydroxypropionyl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus, revealing its subdomain organization and substrate-binding state.

Structural Categorization and identification of electrostatic interactions in two proposed Human Serum Albumin dimerization patterns and dipyridamole interaction.

This study presents high-resolution crystal structures of two HSA dimerization patterns and analyzes electrostatic interactions and dipyridamole binding, showing their potential for drug delivery applications.

Solubility, Hydration, and Sulphate Coordination in Cubic Insulin Crystals from Esrapid™ Monomers Stabilized in Divalent Anionic Form of Citric Acid

This study investigates how water and anion coordination affect insulin's structure and stability across a pH range, revealing pH-dependent electrostatic effects on protein dynamics and stabilization.

A Novel Unorthodox Dimeric Primary Enoyl-CoA Reductase Structure

The paper presents the first dimeric ECR structure from Mesorhizobium metallidurans, revealing structural differences that may impact catalytic activity compared to tetrameric ECRs.

The N-terminal order-disorder transition is a critical determinant for a metamorphosis of IscU

This study identifies the N-terminal order-disorder transition as critical for IscU's metamorphic behavior and shows it can be modulated by a peptide mimic.

Deciphering the altered conformational states of bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus

The paper determines ambient temperature structures of the bifunctional Nmar_1308 enzyme from Nitrosopumilus maritimus, revealing new conformational dynamics relevant to synthetic biology.

Insights into Therapeutic Discovery Through the Kelch Domain Structure of Keap1 at Ambient Temperature

This study reports the structure of the dimeric Keap1 Kelch domain at ambient temperature and identifies a novel compound, CNN, as a potential lead for Keap1 inhibition.

Production, Purification, and Crystallization of Recombinant HER2 Tyrosine Kinase Domain (HER2-TKD) as a Platform for Structure-Based Drug Screening

This study produces and purifies soluble recombinant HER2-TKD for structural studies and drug screening.

Expression, Purification, and Crystallization of Recombinant Human ABL-1 Kinase for Structure-Based Drug Screening Applications

This paper describes the expression, purification, and crystallization of recombinant human ABL-1 kinase for structural analysis and drug screening in CML.

Structural Analysis and Docking Studies of FK506-Binding Protein 1A

This study presents the crystal structure of FKBP1A at 1.05 Å resolution and performs docking studies to explore potential drug repurposing opportunities.

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions

This study presents the crystal structure of human SOD1 and analyzes its structural dynamics and interactions with potential drug candidates for ALS treatment.

X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers

The paper uses X-ray crystallography and hydrogen-deuterium exchange to study insulin analog dynamics, showing faster deuterium exchange and structural insights into modified insulin monomers.

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF-Trap

This study presents near-physiological structures of the Fc fragment from a biosimilar VEGF-Trap and shows structural plasticity through molecular dynamics simulations.

Structural Characterization of TRAF6 N-terminal for Therapeutic Uses

The paper presents the structure of TRAF6 N-terminal domain at 2.6 Å resolution, providing insights into its domain organization and zinc-binding, which are critical for its function and therapeutic targeting.

The crystal structure of Vibrio cholerae (6-4) photolyase reveals interactions with cofactors and a DNA binding region

The paper determines the crystal structure of Vibrio cholerae (6-4) photolyase, revealing interactions with three cofactors and a potential DNA binding region.

Case Study of High-Throughput Drug Screening and Remote Data Collection for SARS-CoV-2 Main Protease by Using Serial Femtosecond X-ray Crystallography

This study demonstrates a high-throughput drug screening protocol using serial femtosecond X-ray crystallography for SARS-CoV-2 main protease, achieving 120 images/second with a new detector.