Caihong Zhu

This study shows that PGRN deficiency causes lipid droplet accumulation in microglia through the STAT3-GPAT3 axis, and identifies potential therapeutic strategies.

This study shows that elevated TAF15 expression in neurons causes oxidative stress, neurotoxicity, and FTD-like behaviors, which can be reversed by antioxidants.

This study identifies an H-latch conformational switch in PrPC that drives prion toxicity and shows that disrupting this switch can protect against prion-related neurodegeneration.

This study investigates the role of Msr1 in prion clearance and pathogenesis, finding that Msr1 deficiency does not affect prion disease progression or neuroinflammation.

The paper identifies protective anti-prion antibodies in human immunoglobulin repertoires and finds they are present in healthy individuals without associated pathologies.

This study shows that SARM1 deficiency accelerates prion disease progression by upregulating XAF1, leading to increased neuronal apoptosis.

This study investigates the role of Del-1 in prion disease progression and finds that its absence does not affect prion pathogenesis, clearance, or neuroinflammation in mice.