Jenny F. Nathans

A prime-editing recorder in one mouse embryo yields a dated, zygote-rooted lineage tree of 1.28M cells at E13.5, enabling clonal dominance, sibling-fate and cell-type coupling analyses.

The paper designs and characterizes diverse genomic parts for precise genome editing and molecular recording in mammalian cells.

This paper identifies epigenetic features affecting prime editing efficiency and shows how chromatin state can be manipulated to enhance or reduce editing efficiency at specific genomic loci.

This paper introduces ENGRAM, a method to genomically record enhancer and signal transduction activity in mammalian cells, demonstrating its ability to track multiple transcriptional reporters with high fidelity.