Haedong Kim

A prime-editing recorder in one mouse embryo yields a dated, zygote-rooted lineage tree of 1.28M cells at E13.5, enabling clonal dominance, sibling-fate and cell-type coupling analyses.

The paper introduces LAMPRAs to measure how cis-regulatory element composition affects gene expression using synthetic loci.

The paper develops monoclonal gastruloids from single mouse embryonic stem cells and uses DNA Typewriter to reveal heritable lineage biases in early development.

The paper designs and characterizes diverse genomic parts for precise genome editing and molecular recording in mammalian cells.

This paper identifies epigenetic features affecting prime editing efficiency and shows how chromatin state can be manipulated to enhance or reduce editing efficiency at specific genomic loci.

The paper identifies TUT4 and TUT7 as regulators of miRNA arm switching through uridylation, showing its role in glioblastoma progression.

AQ-seq improves miRNA quantification by reducing ligation bias, revealing new miRNA variants and modifications.