Author

Leah Gottlieb

University of PennsylvaniaORCID 0000-0002-0276-7593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Elaine J. Marchi· 2 shared Gholson J. LyoniD· 2 shared Ronen MarmorsteiniD· 2 shared Agnes Y. ParkiD· 1 shared Ahmed Ismail· 1 shared Alfonso Caro‐LlopisiD· 1 shared Alison J. SeboldiD· 1 shared Ana Luı́sa CarvalhoiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Elaine J. Marchi

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2 papers

Recent·Most cited

Expanding the Phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome

Gholson J. Lyon, Marall Vedaie, Travis Besheim, Agnes Y. Park, Elaine J. Marchi, Leah Gottlieb, Tzung‐Chien Hsieh, Hannah Klinkhammer, Katherine Sandomirsky, Hanyin Cheng, Lois Janelle Starr, Isabelle Preddy, Marcellus Tseng, Quan Li, Yu Hu, , Ellen M. Herr-Israel

The paper expands the phenotypic spectrum of NAA10 and NAA15-related neurodevelopmental syndromes by analyzing clinical data from 106 NAA10 and 66 NAA15 variant carriers, revealing variable severity and multi-system involvement.

medRxiv · Aug 22, 2022 · PreprintGenetic & Genomic Medicine

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

Hyae Yon Kweon, Mi-Ni Lee, Max Johannes Dörfel, Seungwoon Seo, Leah Gottlieb, Thomas Papazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael J. Flory, Jonathan Crain, Alison J. Sebold, Scott K. Lyons, Ahmed Ismail, , Gholson J. Lyon

The paper identifies Naa12 as a compensatory N-terminal acetyltransferase that rescues Naa10 deficiency in mice, revealing its role in amino-terminal acetylation.

eLife · Aug 6, 2021Peer-reviewedDevelopmental Biology