Multi-objective Engineering of Trimethylamine Monooxygenase for Improved Thermostability and Cofactor Use
Ruite Xiang, Martin Floor, Rasmus Ree, Albert Cañellas-Solé, Pål Puntervoll, Sergi Rodà, Gro Elin Kjæreng Bjerga, Vı́ctor Guallar
This paper improves an enzyme's thermostability and cofactor compatibility through multi-objective engineering, achieving variants with better heat resistance and higher cofactor activity retention.
bioRxiv · Apr 12, 2026 · PreprintMolecular Biology