FAD mutations suppress brain angiogenesis and neuroprotection by reducing γ-secretase processing and dimerization of VEGFR2.
Rukmani Pandey, Amira Zarrouk, Poulomi Dey, Elizabeth Levendosky, Gilles Carpentier, Patrick R. Hof, Anastasios Georgakopoulos, Nikolaos K. R K Robakis
This study shows FAD mutations reduce VEGFR2 dimerization and downstream angiogenesis and neuroprotection by increasing VCTF1 accumulation.
bioRxiv · Jun 30, 2026 · PreprintNeuroscience