Patrick R. Hof

This study examines how cortical asymmetry and its developmental changes relate to brain connectivity across three cohorts from birth to 22 years.

This paper compares neocortical sulcal anatomy across nine pinniped species to understand how cortical organization changes with adaptation to marine environments.

This study shows FAD mutations reduce VEGFR2 dimerization and downstream angiogenesis and neuroprotection by increasing VCTF1 accumulation.

The paper identifies human-specific transcriptomic and regulatory features in the cerebellum, including ZP2's role in synapse development and regulation.

The paper develops a method to label and map myelinated fibers in human brain tissue using light-sheet fluorescence microscopy and automated image analysis, enabling high-resolution structural characterization.

This study evaluates the effectiveness of near-infrared light therapy for neurodegenerative diseases by measuring light penetration through human skulls and its biological effects on neurons and C. elegans.

The paper compares single-neuron projection patterns from the basolateral amygdala to the frontal cortex in mice and macaques, finding differences in connectivity organization.

This paper introduces a semi-supervised segmentation model for identifying supragranular and infragranular layers in human cerebral cortex MRI scans with high precision.

The paper characterizes the evolution of the brain N-glycome across primates, finding increased complexity and human-specific sialic acid linkage changes.

The paper uses single nucleus RNA-sequencing to analyze human cortical areas, revealing cell type proportions and gene expression patterns that correlate with functional connectivity and areal specialization.

The paper uses MAPseq to analyze BLA neuron projections in macaques, finding that many neurons project to multiple brain regions and form structured networks.

This study shows that neuronal TIMP2 regulates hippocampus-dependent memory by controlling extracellular matrix accumulation and adult neurogenesis.

The paper provides a guide to the BRAIN Initiative Cell Census Network (BICCN) data ecosystem, its tools, and resources for analyzing brain cell types across species.

This paper develops a method to 3D molecularly characterize cleared human brain tissues using light-sheet fluorescence microscopy.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper develops an imaging pipeline to create a cell census of the human cerebral cortex using MRI, immunohistochemistry, and light-sheet fluorescence microscopy.

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

The paper presents a method combining immunostaining, SWITCH/TDE clearing, and confocal microscopy to map neurons in human cerebral cortex slices, addressing challenges in labeling and clearing.

This study creates two high-resolution anatomical atlases of prenatal human brains at PCW 15 and 21, annotated with gene expression and cytoarchitecture to identify developmental features.

The paper identifies thermogenetic features in cetacean brains that may relate to their aquatic lifestyle and brain evolution.

The paper identifies structural brain differences in male and female rat models of Fragile X syndrome, including reduced axonal caliber in the splenium of the corpus callosum.

This study identifies an adolescent-sensitive period for top-down neurons in mice, where heightened local drive during adolescence leads to long-term attentional behavior changes.

This study identifies a functional gene module associated with selective neuronal vulnerability in Alzheimer’s disease using integrated molecular and genetic data from mice and humans.

NeuroInfo automatically registers experimental mouse brain sections with a 3D atlas to accurately identify brain regions, improving navigation and reducing observer error.

The paper shows that treating SH-SY5Y cells with okadaic acid induces high molecular weight tau-immunoreactive proteins, possibly representing tau oligomers or phospho-proteins.

This study shows that chemogenetic inhibition in rhesus monkeys affects behavior based on the level of receptor transduction, with higher transduction linked to greater behavioral impairment.