Author

Eric L. Smith

Brigham and Women's HospitalORCID 0000-0002-0296-7587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:contrastive learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Alissa Jamie CooperiD· 1 shared Anusuya M. RamasubramanianiD· 1 shared Berkay ŞímșekiD· 1 shared Brady James· 1 shared Carlotta CostaiD· 1 shared Damien VasseuriD· 1 shared Elliott Joseph BreaiD· 1 shared Gaelle Nafeh· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Alissa Jamie CooperORCID

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2 papers

Recent·Most cited

Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

Damien Vasseur, Shin Saito, Gunsagar Singh Gulati, Garyoung Gary Lee, Yasmin Nabil Laimon, Berkay Şímșek, Maddie Lerner, Hyeonseo Cho, Yixiang Li, Tianchu Wang, Ji-Heui Seo, Hunter Savignano, Brady James, Ze Zhang, Karl Semaan, , Matthew G. Oser

This study investigates how transcription factor subtypes in small cell lung cancer influence response and resistance to DLL3-targeted therapy, revealing subtype-specific mechanisms of resistance.

bioRxiv · Apr 8, 2026 · PreprintCancer Biology

High-throughput Image-based Clustering of CAR-T/Tumor Cocultures for Rapid and Facile Hit Identification

Zhi Xu, Xueqi Liu, Kirby Madden-Hennessey, Jordan Urbani, Shahryar Khoshtinat Nikkhoi, Anusuya M. Ramasubramanian, Kartika Venugopal, Qi Zhao, Eric L. Smith, Yun Fu

This paper introduces a novel image clustering approach for CAR-T/tumor cocultures using U-net and clustering algorithms, demonstrating superior performance in classification and data interpretation.

bioRxiv · Aug 28, 2024 · PreprintCell Biology