Compromised beta-cell identity in type 2 diabetes
Pritha Dutta, Nadège Merabet, Rick Quax, Françoise Carlotti, Peter M. A. Sloot
The paper develops a mathematical model to study how chronic hyperglycemia affects beta-cell transcription factors PDX1 and MAFA, identifying FOXO1 as a potential therapeutic target for restoring beta-cell identity.
bioRxiv · Mar 20, 2023 · PreprintSystems Biology