Author

Pritha Dutta

University of WaterlooORCID 0000-0001-9342-4176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1 Approach:simulation· 1

Frequent Co-Authors

Anita T. LaytoniD· 1 shared Anna C. NelsoniD· 1 shared Ashlee N. Ford VersyptiD· 1 shared Brenda Jane SmithiD· 1 shared Carley V. Cook· 1 shared Edwina YeoiD· 1 shared Françoise CarlottiiD· 1 shared Lauryn Keeler BruceiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperSystems Biology

Anita T. LaytonORCID

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3 papers

Recent·Most cited

Mathematical Modeling of Bone Remodeling after Surgical Menopause

Anna C. Nelson, Edwina Yeo, Yun Zhang, Carley V. Cook, Sophie Fischer-Holzhausen, Lauryn Keeler Bruce, Pritha Dutta, Samaneh Gholami, Brenda Jane Smith, Ashlee N. Ford Versypt

The paper develops a mathematical model to simulate bone remodeling after surgical menopause, showing increased bone loss initially and a long-term rebound in bone density.

Frontiers in Systems Biology · Feb 11, 2026Peer-reviewedSystems Biology

Unraveling the Mechanistic Links Between Blood Pressure Regulation and Calcium-Magnesium Homeostasis: Insights into Hypertension, Hyperparathyroidism, and Mineral Disorders

Pritha Dutta, Anita T. Layton

This study develops a computational model of blood pressure regulation and calcium-magnesium homeostasis in rats, showing how disruptions in these systems affect each other and contribute to hypertension and hyperparathyroidism.

PLoS ONE · Feb 4, 2026Peer-reviewedSystems Biology

Compromised beta-cell identity in type 2 diabetes

Pritha Dutta, Nadège Merabet, Rick Quax, Françoise Carlotti, Peter M. A. Sloot

The paper develops a mathematical model to study how chronic hyperglycemia affects beta-cell transcription factors PDX1 and MAFA, identifying FOXO1 as a potential therapeutic target for restoring beta-cell identity.

bioRxiv · Mar 20, 2023 · PreprintSystems Biology