Françoise Carlotti

The paper constructs a healthy human pancreas reference atlas to contextualize disease states and benchmark models.

This study shows that R-BHB alters human islet cell composition and identity, while S-BHB does not, suggesting ketone metabolism influences beta cell function.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

The paper infers post-transcriptional regulatory mechanisms in human islets using cell type-specific eQTLs from single-cell RNA-seq data, linking variants to biological processes in health and disease.

The paper shows that ER stress relief in beta cells promotes proliferation, independent of vascular recovery, by using transgene overexpression and chemical induction.

The paper develops a mathematical model to study how chronic hyperglycemia affects beta-cell transcription factors PDX1 and MAFA, identifying FOXO1 as a potential therapeutic target for restoring beta-cell identity.