Cancer BiologybioRxivPreprint
PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance
Han Wang, Zixi Yun, Yuan Cao…·Hung‐Ying Kao
This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.