Author

Yuan Cao

Case Comprehensive Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Han Wang· 2 shared Hung‐Ying KaoiD· 2 shared Ruth A. KeriiD· 2 shared Sichun YangiD· 2 shared Xinyue Li· 2 shared Zhenghao LiuiD· 2 shared Alexa Adesokan· 1 shared Belinda B. WillardiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Han Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A large, comprehensive labeled MRI dataset of the human lateral ventricle choroid plexus

Ling-Yu Huang, Victor Zeng, Nicolas Raymond, Brendan Stiltner, Willa Molho, Yuan Cao, Deepthi Bannai, Daphne Ying, Emma Oss, Daman Parduman Dhunna, Prachi Patel, Alexa Adesokan, Morgan Hricay, Victoria Lyons, Noah Tolentino, , Paulo Lizano

The paper introduces DataPlex, a large labeled MRI dataset of the human lateral ventricle choroid plexus to improve segmentation accuracy for clinical and research applications.

bioRxiv · Oct 11, 2026 · PreprintNeuroscience

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

Han Wang, Yuxuan Luo, Sandeep Artham, Qianqian Wang, Yi Peng, Zixi Yun, Xinyue Li, Chen Wu, Zhenghao Liu, Kristen L. Weber-Bonk, Chun-Peng Pai, Yuan Cao, Jiangan Yue, Sunghee Park, Ruth A. Keri, , Sichun Yang

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

Molecular Cancer Therapeutics · Sep 10, 2025Peer-reviewedCancer Biology

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

Han Wang, Zixi Yun, Yuan Cao, Xinyue Li, Zhenghao Liu, Chun-Peng Pai, Chen Wu, Junrong Yue, Gina Lin, Jackie Cai, Belinda B. Willard, Sichun Yang, Ruth A. Keri, William P. Schiemann, John Alan Diehl, Hung‐Ying Kao

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.

bioRxiv · May 15, 2025 · PreprintCancer Biology

Proteomic Characterization of Serum Small Extracellular Vesicles in Human Breast Cancer

Ganfei Xu, Weiyi Huang, Shaoqian Du, Minjing Huang, Jiacheng Lyu, Fei Zhou, Rongxuan Zhu, Yuan Cao, Jingxuan Xv, Ning Li, Guoying Yu, Bing‐Hua Jiang, Olivier Gires, Lei Zhou, Hongwei Zhang, , Hongxia Wang

The paper characterizes serum small extracellular vesicles (sEVs) proteomics in breast cancer patients, identifying distinct protein signatures and potential biomarkers for diagnosis and prognosis.

bioRxiv · Nov 26, 2021 · PreprintBioinformatics

Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency

Yongzheng Li, Boxin Xue, Mengling Zhang, Liwei Zhang, Yingping Hou, Yizhi Qin, Haizhen Long, Qian Peter Su, Yao Wang, Xiaodong Guan, Yanyan Jin, Yuan Cao, Guohong Li, Yujie Sun

This study uses super-resolution imaging to show that replication origins are preferentially fired at the periphery of TADs due to chromatin re-organization linked to transcription and CTCF.

Genome biology · Jul 12, 2021Peer-reviewedGenomics