Author

Hung‐Ying Kao

Case Comprehensive Cancer CenterORCID 0000-0003-4535-0314Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Han Wang· 2 shared Ruth A. KeriiD· 2 shared Sichun YangiD· 2 shared Xinyue Li· 2 shared Yuan Cao· 2 shared Zhenghao LiuiD· 2 shared Belinda B. WillardiD· 1 shared Chen WuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Han Wang

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2 papers

Recent·Most cited

Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedSep 10, 2025

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

Han Wang, Yuxuan Luo, Sandeep Artham…·Sichun Yang

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

DOI 10.1158/1535-7163.mct-25-0405

humanproteomics

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Cancer BiologybioRxivPreprintMay 15, 2025

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

Han Wang, Zixi Yun, Yuan Cao…·Hung‐Ying Kao

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.

1 citation

humanscRNA-seq

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