The atypical filament assembly underpins the inflammasome-independent functions of IFI16.
Archit Garg, Ewa Niedzialkowska, Jeffrey J Zhou, Jasper Moh, Edward H. Egelman, Jungsan Sohn
This study reveals the structural basis for IFI16's inflammasome-independent functions through cryo-EM and computational analysis of its unique filament assembly.
The EMBO Journal · Nov 5, 2025Peer-reviewedBiophysics