BiochemistryCell ReportsPeer-reviewed
Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS
Jacob Lueck, Alexander Strom, Stephanie Torres…·Jungsan Sohn
This study shows that cGAS dimerization on dsDNA forms gel-like condensates, which activate cGAS and protect dsDNA, while single-stranded RNA can dissolve these condensates.
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