Author

Jungsan Sohn

Johns Hopkins UniversityORCID 0000-0002-9570-2544Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jungsan Sohn1 paper · Johns Hopkins University School of Medicine

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Shuai Wu· 3 shared Stephanie Torres· 3 shared Brendan AntiochosiD· 2 shared Jasper MohiD· 2 shared Alexander Strom· 1 shared Archit GargiD· 1 shared Christina M StallingsiD· 1 shared Edward H. EgelmaniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

Shuai Wu

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Author profile →

4 papers

Recent·Most cited

cGAS bends unpaired DNA to form an unconventional structure that hyperactivates the innate immune response

Shuangshuang Yang, Shuai Wu, Silian Chen, Xin Li, Iryna Chelepis, Smaranda Willcox, Katherine Camille Barnett, Xiaoqing Hu, Guannan Huang, W. June Brickey, Joseph A. Duncan, Wei-Chun Chou, Pengda Liu, William G. Fusco, Stephanie Torres, , Jenny P.‐Y. Ting

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

bioRxiv · May 25, 2026 · PreprintImmunology

Protein-DNA mesh assembly drives dsDNA-specific and duplex length-dependent activation of cGAS

Shuai Wu, Christina M Stallings, Stephanie Torres, Brendan Antiochos, Jungsan Sohn

This study shows cGAS forms a protein-dsDNA mesh that enables dsDNA-specific and length-dependent activation through higher-order assembly.

bioRxiv · May 21, 2026 · PreprintBiophysics

Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS

Jacob Lueck, Alexander Strom, Stephanie Torres, Shuai Wu, Jasper Moh, Hannah Wendorff, Brendan Antiochos, Jungsan Sohn

This study shows that cGAS dimerization on dsDNA forms gel-like condensates, which activate cGAS and protect dsDNA, while single-stranded RNA can dissolve these condensates.

Cell Reports · Jan 23, 2026Peer-reviewedBiochemistry

The atypical filament assembly underpins the inflammasome-independent functions of IFI16.

Archit Garg, Ewa Niedzialkowska, Jeffrey J Zhou, Jasper Moh, Edward H. Egelman, Jungsan Sohn

This study reveals the structural basis for IFI16's inflammasome-independent functions through cryo-EM and computational analysis of its unique filament assembly.

The EMBO Journal · Nov 5, 2025Peer-reviewedBiophysics