First inhibitor of a bacterial two-partner secretion system.
Alfred Hartojo, Laurence Don Wai Luu, Lachlan S. R. Adamson, Kyra Majors, Ashleigh S. Paparella, Peggy A. Cotter, Richard Johnson, Matthew Thomas Doyle
This paper identifies a peptide inhibitor of FhaC, a TpsB protein involved in bacterial virulence, showing it inhibits exoprotein secretion and reduces virulence correlates.
bioRxiv · Jan 12, 2026 · PreprintBiochemistry