Author

Lachlan S. R. Adamson

The University of SydneyORCID 0000-0002-9862-9557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:mixed model· 1

Frequent Co-Authors

Yu Heng LauiD· 3 shared Frank SainsburyiD· 2 shared Li Chen CheahiD· 2 shared Matthew Thomas DoyleiD· 2 shared Reginald YoungiD· 2 shared Taylor N. SzyszkaiD· 2 shared Aidan B. GrosasiD· 1 shared Alanah Grace EisenhuthiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersSynthetic Biology

Yu Heng LauORCID

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Author profile →

5 papers

Recent·Most cited

Mechanism of phospholipid transport to the bacterial outer membrane by TAM.

Alanah Grace Eisenhuth, Lachlan S. R. Adamson, Catherine Zhang, Ghaeath S. K. Abbas, Rachel A. North, Denisse L. Leyton, Harris D. Bernstein, Simon H. J. Brown, Alastair G. Stewart, Constance B. Bailey, Anthony Simon Don, Aidan B. Grosas, Matthew Thomas Doyle

This study identifies TAM as a bacterial phospholipid transport system, revealing its structure and mechanism for lipid delivery to the outer membrane.

bioRxiv · Mar 24, 2026 · PreprintBiochemistry

First inhibitor of a bacterial two-partner secretion system.

Alfred Hartojo, Laurence Don Wai Luu, Lachlan S. R. Adamson, Kyra Majors, Ashleigh S. Paparella, Peggy A. Cotter, Richard Johnson, Matthew Thomas Doyle

This paper identifies a peptide inhibitor of FhaC, a TpsB protein involved in bacterial virulence, showing it inhibits exoprotein secretion and reduces virulence correlates.

bioRxiv · Jan 12, 2026 · PreprintBiochemistry

High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages

Taylor N. Szyszka, Rezwan Siddiquee, Alex Loustau, Lachlan S. R. Adamson, Claire Rennie, Tiancheng Huang, Reginald Young, Andrew Care, Yu Heng Lau

This paper describes an in vitro method for packaging synthetic cargo into encapsulin protein cages with high fidelity and broad compatibility, outperforming in cellulo assembly.

Angewandte Chemie International Edition · Mar 26, 2025Peer-reviewedBiochemistry

Pore structure controls stability and molecular flux in engineered protein cages

Lachlan S. R. Adamson, Nuren Tasneem, Michael P. Andreas, William Close, Eric N. Jenner, Taylor N. Szyszka, Reginald Young, Li Chen Cheah, Alexander R. Norman, Hugo MacDermott-Opeskin, Megan L. O’Mara, Frank Sainsbury, Tobias W. Giessen, Yu Heng Lau

This study investigates how pore structure affects stability and molecular flux in engineered protein cages through design, structural analysis, and simulations.

Science Advances · Feb 4, 2022Peer-reviewedSynthetic Biology

An artificial self-assembling nanocompartment for organising metabolic pathways in yeast

Li Chen Cheah, Terra Stark, Lachlan S. R. Adamson, Rufika Shari Abidin, Yu Heng Lau, Frank Sainsbury, Claudia Estelle Vickers

The paper demonstrates an artificial nanocompartment in yeast that enhances metabolic pathway efficiency by stabilizing enzymes and reducing toxicity.

ACS Synthetic Biology · Sep 30, 2021Peer-reviewedSynthetic Biology