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Spaceflight-relevant microgravity triggers a sublethal Parkinson's-like dopaminergic decline in human neurons and organoids.
Nilufar Ali, Shehbeel Arif, Max-Florian Mortimer…·Julia Thom Oxford
72 h of clinostat-simulated microgravity pushed human dopaminergic organoids and SH-SY5Y neurons into a sublethal Parkinson's-like state: mitochondrial dysfunction, reduced translation, tyrosine hydroxylase loss, mitochondrial DNA release, no apoptosis.
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