Nilufar Ali

The paper proposes a VEN Fatigue Hypothesis to explain duration-dependent emotion recognition decline in long-duration spaceflight, supported by multi-omics and neuroimaging data.

72 h of clinostat-simulated microgravity pushed human dopaminergic organoids and SH-SY5Y neurons into a sublethal Parkinson's-like state: mitochondrial dysfunction, reduced translation, tyrosine hydroxylase loss, mitochondrial DNA release, no apoptosis.

This study shows that aging impairs mesenchymal stem cells by reducing osteogenesis, increasing adipogenesis, and decreasing mitochondrial mechanical responsiveness.