Phosphoinositides protonation states dictate AKT1 binding with membrane
Kirtika Jha, M. Z. I. Sarkar, Krishnakanth Baratam, Jayashree Nagesh, Thomas John Pucadyil, Anand Srivastava
This study shows that phosphoinositide protonation microstates determine AKT1 membrane binding specificity and how mutations alter this interaction.
bioRxiv · Sep 10, 2026 · PreprintBiophysics