Thomas John Pucadyil

Dynamin-2 is a fission factor for SNX1-coated endosomal tubules

This study identifies Dynamin-2 as the fission factor for SNX1-coated endosomal tubules, showing it is required for tubule scission and cargo recycling.

Phosphoinositides protonation states dictate AKT1 binding with membrane

This study shows that phosphoinositide protonation microstates determine AKT1 membrane binding specificity and how mutations alter this interaction.

Division-arrest induced filamentation protects uropathogenic Escherichia coli from killing by the cathelicidin antimicrobial peptide LL-37

This study shows that LL-37 kills dividing E. coli by disrupting membranes during late division, while filamentation confers resistance, suggesting filamentation may aid UPEC survival during infections.

Membrane remodeling by the Bacterial Dynamin-like Protein (BDLP) from Nostoc punctiforme

This study investigates the membrane remodeling activities of BDLP from Nostoc punctiforme, showing it functions as a scaffold regulated by nucleotide binding rather than mediating fusion.

Vacuolar protein sorting-associated protein 1 (Vps1) has membrane constricting and severing abilities required for endosomal protein trafficking

This study identifies Vps1's membrane constricting and severing roles in endosomal trafficking, showing its requirement for fission and protein sorting in yeast.

Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria

This study identifies Wag31's role in lipid homeostasis in mycobacteria by showing its tethering activity and interactions with membrane proteins.