BioengineeringMolecular TherapyPeer-reviewed
Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells
Lauren E. Sarko, David Givand, Brendan Rattin…·Krishanu Saha
This paper introduces a method to enhance T cell therapy by using a CAR targeting uPAR to eliminate dysfunctional T cells through directed fratricide.