Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells
Lauren E. Sarko, David Givand, Brendan Rattin, Claire Shepley, Anna Tommasi, Allen Attar, Rachel Taylor, Benjamin Kutler, Roshini M. Traynor, Anika Upadhyaya, Mackenzie Mnuk, Cavin Gehrke, Nat Murren, Tyler Kent Ulland, Christian M. Capitini, , Krishanu Saha
This paper introduces a method to enhance T cell therapy by using a CAR targeting uPAR to eliminate dysfunctional T cells through directed fratricide.
Molecular Therapy · Jun 3, 2026Peer-reviewedBioengineering