Hoor Al-Hasani

This paper introduces ValidaTe, a framework to predict and mitigate off-target liabilities in TCR-mimic antibodies, demonstrating its effectiveness with CTA MAGE-A4 targets.

EpiTox identifies and evaluates pHLA off-targets to improve preclinical safety screening for TCRm therapies, highlighting cross-reactivity with novel epitopes.

This paper introduces EpiPredict, a machine learning framework that identifies off-target pHLA interactions for TCRm antibodies beyond sequence similarity, validated through experimental assays.