NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development
Hsiang‐i Tsai, Xiaobin Zeng, Longshan Liu, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Huanxi Zhang, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Yijing Tao, Changxi Wang, Jing Crystal Zhao, John Eriksson, , Hongbo Chen
The paper identifies NF45/NF90-mediated rDNA transcription as a novel target for immunosuppressants, showing that inhibiting it suppresses T cell activation more effectively than FK506.
EMBO Molecular Medicine · Feb 8, 2021Peer-reviewedMolecular Biology