Author

Zirong Bi

Guangzhou LaboratoryORCID 0000-0002-9465-8035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Changxi WangiD· 1 shared Dandan SuiD· 1 shared Deqi CheniD· 1 shared Fang ChengiD· 1 shared Feng ZhangiD· 1 shared Gan Liu· 1 shared Haopeng LiniD· 1 shared Hongbo CheniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Changxi WangORCID

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2 papers

Recent·Most cited

Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism

Haopeng Lin, Xin Liu, Feng Zhang, Deqi Chen, Xiaoxiao Xie, Qifei Dong, Jiawei Yan, Jiaxiang Yin, Zirong Bi, Zhihua Dou, Yingling Jiang, Kuo Jiang, Tongran Zhang, Peng Xue, Wei Peng, , Huisheng Liu

This study identifies PKM1-regulated PEP metabolism as a key factor in improving functional maturation of human stem-cell derived β cells by enhancing calcium response and insulin secretion.

Nature Communications · Dec 21, 2025Peer-reviewedCell Biology

NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development

Hsiang‐i Tsai, Xiaobin Zeng, Longshan Liu, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Huanxi Zhang, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Yijing Tao, Changxi Wang, Jing Crystal Zhao, John Eriksson, , Hongbo Chen

The paper identifies NF45/NF90-mediated rDNA transcription as a novel target for immunosuppressants, showing that inhibiting it suppresses T cell activation more effectively than FK506.

EMBO Molecular Medicine · Feb 8, 2021Peer-reviewedMolecular Biology