High throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by Methylated DNA sequencing (MeD-seq) of LpnPI digested fragments
Teoman Deger, Ruben Boers, Vanja de Weerd, Lindsay Angus, Marjolijn M. J. van der Put, Joachim Boers, Zakia Azmani, Wilfred F. J. van IJcken, Dirk Jan Grünhagen, Lisanne F. van Dessel, Martijn P. Lolkema, Cornelis Verhoef, Stefan Sleijfer, John W.M. Martens, Joost H. Gribnau, Saskia M. Wilting
This paper validates MeD-seq for cfDNA methylation profiling in cancer patients, showing distinct pre-surgical methylation patterns compared to healthy donors.
Clinical Epigenetics · Oct 20, 2021Peer-reviewedGenomics