Author

F Saudek

Charles UniversityORCID 0000-0002-0448-4351Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:rat· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Jan KřížiD· 2 shared K. ZacharovováiD· 2 shared Kateřina BittenglováiD· 2 shared Peter GirmaniD· 2 shared Tomáš KoblasiD· 2 shared Filip TichánekiD· 1 shared Ivan LeontovyčiD· 1 shared Lukáš ValihrachiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersCell Biology

Jan KřížORCID

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2 papers

Recent·Most cited

Heterogeneity in cell-cycle dynamics of synthetic mRNA-induced β-cell proliferation

Kateřina Bittenglová, K. Zacharovová, Filip Tichánek, Ivan Leontovyč, Peter Girman, Jan Kříž, F Saudek, Tomáš Koblas

This study induces β-cell proliferation in rats using synthetic mRNAs and identifies heterogeneity in cell-cycle dynamics, revealing variability in G1 duration and division completion.

bioRxiv · Sep 14, 2026 · PreprintCell Biology

Stimulation of rodent and human beta-cell proliferation using synthetic modified mRNAs encoding cell cycle regulators

Tomáš Koblas, Kateřina Bittenglová, Pavel Abaffy, K. Zacharovová, Peter Girman, Lukáš Valihrach, Jan Kříž, F Saudek

This study uses synthetic modified mRNAs to stimulate beta-cell proliferation in rodents and humans, showing temporary activation of cell cycle pathways without sustained proliferation.

bioRxiv · Aug 24, 2026 · PreprintBioengineering