Pavel Abaffy

Stimulation of rodent and human beta-cell proliferation using synthetic modified mRNAs encoding cell cycle regulators

This study uses synthetic modified mRNAs to stimulate beta-cell proliferation in rodents and humans, showing temporary activation of cell cycle pathways without sustained proliferation.

Single-nucleus transcriptome analysis provides new insights into B chromosome elimination in sorghum

The paper uses snRNA-seq to study B chromosome elimination in sorghum embryos, identifying two subpopulations of B-containing nuclei with distinct transcriptional profiles.

PU.1-driven enrichment enables microglia profiling from frozen brain tissue using the high-throughput Smart-seq3xpress method

The paper introduces a method to profile microglia from frozen brain tissue using PU.1 as a marker and Smart-seq3xpress, showing improved transcriptomic data compared to standard protocols.

Spatiotemporal transcriptomic map of ischemic brain injury

This study maps the spatiotemporal transcriptomic changes in mouse brain tissue after ischemic injury, revealing glial cell responses and their role in neuroinflammation.

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration

This study identifies Regeneration Initiating Cells (RICs) in Xenopus laevis tail regeneration using single cell and spatial transcriptomics, showing their role in initiating regeneration by modifying the extracellular matrix.

Evolutionary conservation of maternal RNA localization in fishes and amphibians revealed by TOMO-Seq

The paper uses TOMO-Seq to compare maternal RNA localization across four fish and amphibian species, revealing diverse localization patterns and poor correlation between vegetally localized genes.

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

The paper analyzes RNA-Seq data from young and aged mice after ischemic stroke to identify age-related transcriptional changes and inflammatory responses.