Lukáš Valihrach

This study uses isogenic brain organoids to identify early neurodevelopmental changes and hyperexcitability in Gaucher disease, linking lipid dysregulation and neuronal function imbalances to clinical symptoms.

This study uses synthetic modified mRNAs to stimulate beta-cell proliferation in rodents and humans, showing temporary activation of cell cycle pathways without sustained proliferation.

The paper uses snRNA-seq to study B chromosome elimination in sorghum embryos, identifying two subpopulations of B-containing nuclei with distinct transcriptional profiles.

This study evaluates the neuroprotective and anti-apoptotic effects of neural stem cell-derived extracellular vesicles in an in vitro spinal cord injury model, showing reduced apoptosis and improved cytoskeletal stability.

The paper introduces a method to profile microglia from frozen brain tissue using PU.1 as a marker and Smart-seq3xpress, showing improved transcriptomic data compared to standard protocols.

This study maps the spatiotemporal transcriptomic changes in mouse brain tissue after ischemic injury, revealing glial cell responses and their role in neuroinflammation.

This study shows that ISL1 is essential for auditory neuron development and tonotopic organization, but central plasticity cannot fully compensate for peripheral dysfunction.

This study benchmarks small RNA-sequencing methods for miRNA quantification in biofluids, finding no single method outperforms others and highlighting protocol-specific biases.

The paper analyzes RNA-Seq data from young and aged mice after ischemic stroke to identify age-related transcriptional changes and inflammatory responses.

The paper compares 11 reverse transcriptases for single-cell RNA quantification, identifying two top performers that improve sensitivity and clustering resolution in low RNA concentration experiments.