Rodrigo Alvear‐Perez

This study compares postnatal maturation of the gliovascular unit in male and female mice, revealing sex-specific differences in angiogenesis, cell composition, and transcriptomic trajectories regulated by oestrogenic signalling.

The paper identifies astrocyte perisynaptic processes as sites of early translational dysregulation in Alzheimer's disease, linking it to synaptic dysfunction and disease initiation.

This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.